Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Cytochrome P450 4F2

The CYP4F2 gene encodes a member of the cytochrome P450 superfamily of enzymes. It is involved in drug metabolism, in particular coumarin derivates.

Genetests:

Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Coumarin resistance
CYP2A6
CYP2C9
CYP4F2
VKORC1
Disturbances of cytochrome p450 system
CYP1A2
CYP2A6
CYP2C9
CYP2D6
CYP3A4
CYP4F2
Siponimod intolerance
CYP2C9

References:

1.

Caldwell MD et al. (2008) CYP4F2 genetic variant alters required warfarin dose.

external link
2.

Kikuta Y et al. (1999) Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.

external link
3.

Stec DE et al. (2007) Functional polymorphism in human CYP4F2 decreases 20-HETE production.

external link
4.

Orphanet article

Orphanet ID 286575 external link
5.

NCBI article

NCBI 8529 external link
6.

OMIM.ORG article

Omim 604426 external link
7.

Wikipedia article

Wikipedia EN (CYP4F2) external link
Update: Aug. 14, 2020
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