Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Cytochrome P450, family 4, subfamily F, polypeptide 2

This gene encodes a member of the cytochrome P450 superfamily of enzymes. It is involved in drug metabolism, in particular coumarin derivates.

Genetests:

Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Coumarin resistance
CYP2A6
CYP2C9
CYP4F2
VKORC1

References:

1.

Caldwell MD et al. (2008) CYP4F2 genetic variant alters required warfarin dose.

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2.

Kikuta Y et al. (1999) Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.

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3.

Stec DE et al. (2007) Functional polymorphism in human CYP4F2 decreases 20-HETE production.

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4.

Orphanet article

Orphanet ID 286575 [^]
5.

NCBI article

NCBI 8529 [^]
6.

OMIM.ORG article

Omim 604426 [^]
7.

Wikipedia article

Wikipedia EN (CYP4F2) [^]
Update: April 29, 2019