Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Histamine N-methyltransferase

This gene encodes one of two important enzymes metabolizing histamin, so it is not surprising that genetic alterations are associated with allergic diseases. Also, an association with hitamin intolerance is postulated.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Target mutation analysis
Turnaround 20 days
Specimen type genomic DNA

Related Diseases:

Histamine Intolerance
AOC1
HNMT
MAOA
MAOB

References:

1.

Sasaki Y et al. (2000) Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes.

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2.

Yan L et al. (2000) Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.

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3.

Barnes WG et al. (2004) Characterization of a new mRNA species from the human histamine N-methyltransferase gene.

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4.

Sharma S et al. (2005) Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.

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5.

Yamauchi K et al. (1994) Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.

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6.

Price RA et al. (1993) Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity.

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7.

Aksoy S et al. (1996) Human histamine N-methyltransferase gene: structural characterization and chromosomal location.

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8.

Preuss CV et al. (1998) Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.

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9.

OMIM.ORG article

Omim 605238 external link
10.

Orphanet article

Orphanet ID 448453 external link
11.

NCBI article

NCBI 3176 external link
12.

Wikipedia article

Wikipedia EN (Histamine_N-methyltransferase) external link
Update: Aug. 14, 2020
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