Serine threonine kinase 39
There gene product is a threonine kinase downstream the signal cascade from WNK kinases to SLC12A cotransporters. Therefor it may play a significant role in regulation of electrolyte excretion in the distal tubule.
Johnston AM et al. (2000) SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
Wang Y et al. (2009) From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
Cunnington MS et al. (2009) STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.
Update: Sept. 26, 2018