Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Oxidative stress-responsive 1 protein

The gene product is a serine-threonine kinase that plays a role in response to oxidative stress. It may also have a role in signal transduction downstream from WNK kinases to SLC12A cotransporters.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Liddle syndrome
NEDD4
NEDD4L
NR3C2
OXSR1
SCNN1B
SCNN1G
STK39

References:

1.

Daigo Y et al. (1999) Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.

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2.

Tamari M et al. (1999) Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.

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3.

Chen W et al. (2004) Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.

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4.

Anselmo AN et al. (2006) WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

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Update: Sept. 26, 2018