Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Amiloride binding protein 1 (amine oxidase (copper-containing))

The DAO gene encodes a membrane glycoprotein that is reponsible for histamin metabolism. It is postulated that genetic variation are involved in histamin intolerance.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Histamine Intolerance
AOC1
HNMT
MAOA
MAOB

References:

1.

Barbry P et al. (1990) Human kidney amiloride-binding protein: cDNA structure and functional expression.

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2.

Barbry P et al. (1990) Localization of the gene for amiloride binding protein on chromosome 7 and RFLP analysis in cystic fibrosis families.

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3.

Novotny WF et al. (1994) Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.

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4.

Chassande O et al. (1994) The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter.

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5.

Lingueglia E et al. (1993) Molecular cloning and functional expression of different molecular forms of rat amiloride-binding proteins.

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Update: Sept. 26, 2018