Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Solute carrier family 2 (facilitated glucose transporter), member 9

This gene encodes a glucose transporter. The transporter is responsible for urat elemination from renal epithelial cells. Mutation cause an accumulation of urat in these cells. An impaired glucose metabolism can be expected too.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Renal Hypouricemia
SLC22A12
SLC2A9

References:

1.

Phay JE et al. (2000) Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).

[^]
2.

Augustin R et al. (2004) Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.

[^]
3.

Wallace C et al. (2008) Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

[^]
4.

Döring A et. al. (2008) SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.

[^]
5.

Vitart V et. al. (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.

[^]
6.

Anzai N et al. (2008) Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.

[^]
7.

Matsuo H et. al. (2008) Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia.

[^]
8.

Preitner F et al. (2009) Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.

[^]
Update: Sept. 26, 2018