Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Clusterin

The CLU gene encodes a secreted chaperone that can under some stress conditions also be found in the cell cytosol. Genetic variants have been associated with various disorder including Alzheimer, atypical hemolytic uremic syndrome, and focal segmental glomerulosclerosis.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Alzheimer disease
APOE
APP
CLU
CYP2D6
HFE
Hemolytic-Uremic Syndrome
ADAMTS13
C3
C4BPA
C4BPB
CD46
CFB
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
Methylmalonic aciduria
Methylmalonic aciduria and homocystinuria cblC
MMACHC
Methylmalonic aciduria and homocystinuria cblD
MMADHC
Methylmalonic aciduria type mut
MUT
PIGA
PLG
THBD
Focal, segmental glomerulosclerosis (FSGS)
ALG13
ARHGAP24
CLU
Hereditary FSGS type 1
ACTN4
Hereditary FSGS type 2
TRPC6
Hereditary FSGS type 3
CD2AP
Hereditary FSGS type 4
APOL1
Hereditary FSGS type 5
INF2
Hereditary FSGS type 6
MYO1E
Hereditary FSGS type 7
PAX2
ITGA9
LAMA5
NXF5
Apolipoprotein deficiency
APOA5
APOB
APOC1
APOC2
APOC3
APOE
APOL1
APOM
Apolipoprotein A1 deficiency
APOA1
Apolipoprotein A2 deficiency
APOA2
Apolipoprotein F deficiency
APOF
Apolipoprotein H deficiency
APOH
CLU

References:

1.

DeMattos RB et. al. (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

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2.

McLaughlin L et al. (2000) Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.

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3.

Han BH et al. (2001) Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.

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4.

Ghiggeri GM et al. (2002) Depletion of clusterin in renal diseases causing nephrotic syndrome.

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5.

Chen X et al. (2003) Clusterin as a biomarker in murine and human intestinal neoplasia.

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6.

Dietzsch E et al. (1992) Regional localization of the gene for clusterin (SP-40,40; gene symbol CLI) to human chromosome 8p12-->p21.

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7.

Ostermeier GC et al. (2004) Reproductive biology: delivering spermatozoan RNA to the oocyte.

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8.

Jenne DE et al. (1992) Clusterin: the intriguing guises of a widely expressed glycoprotein.

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9.

Zhang H et al. (2005) Clusterin inhibits apoptosis by interacting with activated Bax.

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10.

Tobe T et al. (1991) Assignment of a human serum glycoprotein SP-40,40 gene (CLI) to chromosome 8.

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11.

Zenkel M et al. (2006) Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material.

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12.

Kamboh MI et al. (1991) Genetic studies of human apolipoproteins. XX. Genetic polymorphism of apolipoprotein J and its impact on quantitative lipid traits in normolipidemic subjects.

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13.

Ståhl AL et al. (2009) A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome.

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14.

de Silva HV et al. (1990) Apolipoprotein J: structure and tissue distribution.

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15.

Purrello M et al. (1991) The gene for SP-40,40, human homolog of rat sulfated glycoprotein 2, rat clusterin, and rat testosterone-repressed prostate message 2, maps to chromosome 8.

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16.

O'Bryan MK et al. (1990) Human seminal clusterin (SP-40,40). Isolation and characterization.

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17.

Slawin K et al. (1990) Chromosomal assignment of the human homologue encoding SGP-2.

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18.

de Silva HV et al. (1990) Purification and characterization of apolipoprotein J.

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19.

Murphy BF et al. (1988) SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.

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20.

Kirszbaum L et al. (1989) Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.

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21.

Duguid JR et al. (1989) Changes in brain gene expression shared by scrapie and Alzheimer disease.

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22.

Dragunow M et al. (1995) Clusterin accumulates in dying neurons following status epilepticus.

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23.

Wong P et al. (1993) Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

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24.

Wong P et al. (1994) Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.

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25.

Fink TM et al. (1993) Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene.

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26.

Danik M et al. (1993) Localization of sulfated glycoprotein-2/clusterin mRNA in the rat brain by in situ hybridization.

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27.

Birkenmeier EH et al. (1993) Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14.

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28.

Bertrand P et al. (1995) Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

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29.

Navab M et al. (1997) Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.

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Update: Sept. 26, 2018