Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Glypican 5

The GPC5 gene encodes a cell surface protein forming heparan sulfate proteoglycans and being probably involved in cell division and growth regulation. Variations seem to be associated with nephrotic syndrome.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Nephrotic syndrome
Congenital nephrotic syndrome type 01 (Finnish type)
NPHS1
Congenital nephrotic syndrome type 02
NPHS2
Congenital nephrotic syndrome type 03
PLCE1
Congenital nephrotic syndrome type 04
WT1
Congenital nephrotic syndrome type 05 (Pierson syndrome)
LAMB2
Congenital nephrotic syndrome type 06
PTPRO
Congenital nephrotic syndrome type 07
DGKE
Congenital nephrotic syndrome type 08
ARHGDIA
Congenital nephrotic syndrome type 09
COQ8B
Congenital nephrotic syndrome type 10
EMP2
Congenital nephrotic syndrome type 11
NUP107
Congenital nephrotic syndrome type 12
NUP93
Congenital nephrotic syndrome type 13
NUP205
Donnai-Barrow syndrome
LRP2
GPC5
Glomerulotubular nephropathy
FAT1
Interstitial lung disease with nephrotic syndrome and epidermolysis bullosa
ITGA3
Lipoprotein glomerulopathy
APOE
Schimke Immunoosseous dysplasia
SMARCAL1
XPO5

References:

1.

Neat MJ et al. (2001) Localisation of a novel region of recurrent amplification in follicular lymphoma to an approximately 6.8 Mb region of 13q32-33.

[^]
2.

Mao X et al. (2002) Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: identification of common genomic alterations in disease pathogenesis.

[^]
3.

Yu W et al. (2003) GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines.

[^]
4.

Okamoto K et al. (2011) Common variation in GPC5 is associated with acquired nephrotic syndrome.

[^]
5.

Veugelers M et al. (1997) Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.

[^]
6.

Knuutila S et al. (1998) DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.

[^]
Update: Sept. 26, 2018