Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Growth hormone releasing hormone

The protein encoded by this gene stimulates growth hormone release from the pituitary thru the releasing hormon receptor (GHRHR).

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Isolated growth hormone deficiency type 1B
GH1
GHRH
GHRHR

References:

1.

Russell-Aulet M et al. (1999) In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: evidence for relative GHRH deficiency in aging.

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2.

Kiaris H et al. (1999) Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma.

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3.

Gianotti L et al. (2000) Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans.

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4.

Busto R et al. (2002) The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas.

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5.

Halmos G et al. (2002) Expression of growth hormone-releasing hormone and its receptor splice variants in human prostate cancer.

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6.

Letsch M et al. (2003) Growth hormone-releasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and -independent prostate cancers.

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7.

Jessup SK et al. (2003) Sexual dimorphism of growth hormone (GH) regulation in humans: endogenous GH-releasing hormone maintains basal GH in women but not in men.

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8.

Kanashiro CA et al. (2003) Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.

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9.

Rao VV et al. (1991) The gene for human growth hormone-releasing factor (GHRF) maps to or near chromosome 20p12.

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10.

Shohat M et al. (1991) Deletion of 20p 11.23----pter with normal growth hormone-releasing hormone genes.

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11.

Mitrakou A et al. (1985) Heterogeneity of growth-hormone deficiency.

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12.

Riddell DC et al. (1985) Chromosomal assignment of human sequences encoding arginine vasopressin-neurophysin II and growth hormone releasing factor.

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13.

Ling N et al. (1985) Growth hormone releasing factors.

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14.

Thorner MO et al. (1988) Acceleration of growth rate in growth hormone-deficient children treated with human growth hormone-releasing hormone.

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15.

Mayo KE et al. (1985) Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment.

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16.

Gubler U et al. (1983) Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.

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17.

Thorner MO et al. (1982) Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor.

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18.

Scheithauer BW et al. (1984) Ectopic secretion of a growth hormone-releasing factor. Report of a case of acromegaly with bronchial carcinoid tumor.

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19.

Pérez Jurado LA et al. (1994) Genetic mapping of the human growth hormone-releasing factor gene (GHRF) using two intragenic polymorphisms detected by PCR amplification.

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20.

Zimmerman D et al. (1993) Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation.

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21.

Flavell DM et al. (1996) Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.

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Update: Sept. 26, 2018