Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Vascular endothelial growth factor C

The VEGFC gene encodes a protein that regulates development of lymphatic vessels. Mutations cause autosomal dominant Milroy-like lymphedema. Also the protein seems to play a role in sodium retention in the skin and probably salt-dependent hypertension.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Hereditary lymphedema type 1d
VEGFC
Hypertension
ACE
ACE2
AGT
Benign hyperproreninemia
REN
Monogenic hypertension
Apparent mineralocorticoid excess
HSD11B2
Glucocorticoid triggered hypertension
NR3C1
Hyperaldosteronism
Conn syndrome
ATP1A1
ATP2B3
CACNA1D
CACNA1H
CTNNB1
KCNJ5
Glucocorticoid triggered hypertension
NR3C1
Hyperaldosteronism type 1
CYP11B1
CYP11B2
Hyperaldosteronism type 2
Hyperaldosteronism type 3
KCNJ5
Hyperaldosteronism type 4
CACNA1D
CACNA1H
Hypertension and brachydactyly syndrome
PDE3A
Liddle syndrome
NEDD4
NEDD4L
NR3C2
OXSR1
SCNN1B
SCNN1G
STK39
Pseudohypoaldosteronism
Pseudohypoaldosteronism type 2
CUL3
KLHL3
WNK1
WNK4
Pseudohypoaldosteronism type1
NR3C2
SCNN1A
SCNN1B
SCNN1G
Preeclampsia
APOL1
Preeclampsia 1
Preeclampsia 2
Preeclampsia 3
Preeclampsia 4
STOX1
Preeclampsia 5
CORIN
Salt-sensitive essential hypertension
CYP3A5
VEGFC

References:

1.

Lee J et al. (1996) Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

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2.

Machnik A et al. (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.

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3.

Gordon K et al. (2013) Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema.

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4.

Villefranc JA et al. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.

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5.

Hung CJ et al. (2003) Expression of vascular endothelial growth factor-C in benign and malignant thyroid tumors.

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6.

Karkkainen MJ et al. (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

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7.

Titze J et al. (2010) Sodium sensing in the interstitium and relationship to hypertension.

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8.

Slagman MC et al. (2012) Vascular endothelial growth factor C levels are modulated by dietary salt intake in proteinuric chronic kidney disease patients and in healthy subjects.

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9.

Liu F et al. (2011) Involvement of the lymphatic system in salt-sensitive hypertension in humans.

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10.

Wiig H et al. (2013) Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.

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11.

Joukov V et al. (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

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12.

Orphanet article

Orphanet ID 376917 [^]
13.

NCBI article

NCBI 7424 [^]
14.

OMIM.ORG article

Omim 601528 [^]
15.

Wikipedia article

Wikipedia EN (Vascular_endothelial_growth_factor_C) [^]
Update: April 29, 2019