Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Mitochondrial TRNT gene

The mitochondrial gene MT-TT encodes a transport RNA (tRNA) for threonine (T). The gene is encoded by nucleotides 15888-15953. An association with Parkinson disease is discussed. The ensemble of all mitochondrial genes is tested if a mitochondrial disorder has to be diagnosed.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Grasbon-Frodl EM et al. (1999) Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease.

external link
2.

Brown MD et al. (1992) Mitochondrial tRNA(Thr) mutations and lethal infantile mitochondrial myopathy.

external link
3.

Yoon KL et al. (1991) Mitochondrial tRNA(thr) mutation in fatal infantile respiratory enzyme deficiency.

external link
4.

Jia Z et al. (2013) Coronary heart disease is associated with a mutation in mitochondrial tRNA.

external link
5.

NCBI article

NCBI 4576 external link
6.

OMIM.ORG article

Omim 590090 external link
7.

Orphanet article

Orphanet ID 328936 external link
Update: Aug. 14, 2020
Copyright © 2005-2024 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits