Mitochondrial TRNG gene
The mitochondrial gene MT-TG encodes a transport RNA (tRNA) for glycine (G). The gene is encoded by nucleotides 9991-10058. Diseases caused by mutations include cardiomyopathy, exercise intolerance, and sudden infant death syndrome. The ensemble of all mitochondrial genes is tested if a mitochondrial disorder has to be diagnosed.
Genetests:
Research |
Method |
Carrier testing |
Turnaround |
5 days |
Specimen type |
genomic DNA |
Related Diseases:
References:
1. |
Nishigaki Y et al. (2002) Exercise-induced muscle "burning," fatigue, and hyper-CKemia: mtDNA T10010C mutation in tRNA(Gly).
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2. |
Tomari Y et al. (2003) Decreased CCA-addition in human mitochondrial tRNAs bearing a pathogenic A4317G or A10044G mutation.
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3. |
None (1980) Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies.
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4. |
Merante F et al. (1994) Maternally inherited hypertrophic cardiomyopathy due to a novel T-to-C transition at nucleotide 9997 in the mitochondrial tRNA(glycine) gene.
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5. |
Santorelli FM et al. (1996) Novel mutation in the mitochondrial DNA tRNA glycine gene associated with sudden unexpected death.
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6. |
Graham BH et al. (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator.
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7. |
NCBI article
NCBI 4563
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8. |
OMIM.ORG article
Omim 590035
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Update: Aug. 14, 2020