Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Apolipoprotein M

APOM encodes apolipoprotein M, a protein that plays a role in lipoprotein metabolism and immune modulation.

Expression

Apolipoprotein M is secreted by endothelial cells ans mostly remains membrane bound. It is also be found in HDL and to a lesser degree LDL and triglyceride-rich lipoproteins. PLasma concentration is 0.9µmol/l. 95% is bound to HDL.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Xu N et al. (1999) A novel human apolipoprotein (apoM).

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2.

Wolfrum C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis.

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3.

Albertella MR et al. (1996) Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).

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Update: Sept. 26, 2018