Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

8-oxoguanine DNA glycosylase

The OGG1 gene encodes a mitochondrial enzyme which is probably responsible to repair of damages caused by oxygen radicals. Soatic mutation were found in renal cell carcinomas.

Genetests:

Research Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Nonpapillary renal cell carcinoma
DIRC2
FLCN
HNF1A
HNF1B
OGG1
RNF139
VHL

References:

1.

Ishida T et al. (1999) Structure and chromosome location of human OGG1.

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2.

Audebert M et al. (2000) Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney.

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3.

Banerjee A et al. (2005) Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.

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4.

Wang CL et al. (2006) The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.

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5.

Trapp C et al. (2007) Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice.

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6.

Kovtun IV et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.

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7.

Perillo B et al. (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.

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8.

Aburatani H et al. (1997) Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

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9.

Arai K et al. (1997) Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage.

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10.

Lu R et al. (1997) A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.

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11.

Rosenquist TA et al. (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

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12.

Radicella JP et al. (1997) Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

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13.

Roldán-Arjona T et al. (1997) Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.

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14.

Bjorâs M et al. (1997) Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

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15.

Kuo FC et al. (1997) Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.

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16.

Tani M et al. (1998) Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage.

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17.

Kohno T et al. (1998) Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

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Update: Sept. 26, 2018