Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

8-oxoguanine DNA glycosylase

The OGG1 gene encodes a mitochondrial enzyme which is probably responsible to repair of damages caused by oxygen radicals. Soatic mutation were found in renal cell carcinomas.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Nonpapillary renal cell carcinoma
DIRC2
FLCN
HNF1A
HNF1B
OGG1
RNF139
VHL

References:

1.

Audebert M et al. (2000) Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney.

external link
2.

Kohno T et al. (1998) Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

external link
3.

Tani M et al. (1998) Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage.

external link
4.

Kuo FC et al. (1997) Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.

external link
5.

Bjorâs M et al. (1997) Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

external link
6.

Roldán-Arjona T et al. (1997) Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.

external link
7.

Radicella JP et al. (1997) Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

external link
8.

Rosenquist TA et al. (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

external link
9.

Lu R et al. (1997) A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.

external link
10.

Arai K et al. (1997) Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage.

external link
11.

Aburatani H et al. (1997) Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

external link
12.

Perillo B et al. (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.

external link
13.

Kovtun IV et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.

external link
14.

Trapp C et al. (2007) Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice.

external link
15.

Wang CL et al. (2006) The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.

external link
16.

Banerjee A et al. (2005) Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.

external link
17.

Ishida T et al. (1999) Structure and chromosome location of human OGG1.

external link
18.

Orphanet article

Orphanet ID 484183 external link
19.

NCBI article

NCBI 4968 external link
20.

OMIM.ORG article

Omim 601982 external link
21.

Wikipedia article

Wikipedia EN (Oxoguanine_glycosylase) external link
Update: Aug. 14, 2020
Copyright © 2005-2020 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues