Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Disrupted in renal carcinoma 2

DIRC2 gen encodes a membrane protein. Renal cell carcinoma are found if this gene is disrupted by translocations.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Nonpapillary renal cell carcinoma
DIRC2
FLCN
HNF1A
HNF1B
OGG1
RNF139
VHL

References:

1.

Bodmer D et al. (2002) Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21).

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2.

NCBI article

NCBI 84925 [^]
3.

OMIM.ORG article

Omim 602773 [^]
4.

Orphanet article

Orphanet ID 484197 [^]
5.

Wikipedia article

Wikipedia EN (DIRC2) [^]
Update: April 29, 2019