Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Trehalase

The TREH gene encodes an enzyme that cleaves trehalose, a disaccharide formed in fungi. Mutations cause autosomal dominant trehalase deficiency that is characterized by gastrointestinal symptoms after the ingestion of young mushrooms.

Genetests:

Research Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Trehalase deficiency
TREH

References:

1.

Oesterreicher TJ et al. (2001) Cloning, characterization and mapping of the mouse trehalase (Treh) gene.

[^]
2.

Ruf J et al. (1990) Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.

[^]
3.

Sasai-Takedatsu M et al. (1996) Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage.

[^]
4.

Ishihara R et al. (1997) Molecular cloning, sequencing and expression of cDNA encoding human trehalase.

[^]
Update: Sept. 26, 2018