Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Trehalase

The TREH gene encodes an enzyme that cleaves trehalose, a disaccharide formed in fungi. Mutations cause autosomal dominant trehalase deficiency that is characterized by gastrointestinal symptoms after the ingestion of young mushrooms.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Trehalase deficiency
TREH

References:

1.

Oesterreicher TJ et al. (2001) Cloning, characterization and mapping of the mouse trehalase (Treh) gene.

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2.

Ruf J et al. (1990) Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.

external link
3.

Sasai-Takedatsu M et al. (1996) Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage.

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4.

Ishihara R et al. (1997) Molecular cloning, sequencing and expression of cDNA encoding human trehalase.

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5.

NCBI article

NCBI 11181 external link
6.

OMIM.ORG article

Omim 275360 external link
7.

Orphanet article

Orphanet ID 158077 external link
8.

Wikipedia article

Wikipedia EN (Trehalase) external link
Update: Aug. 14, 2020
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