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Fibronectin 1

The FN1 gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Mutation of the gene cause autosomal dominant familial glomerular nephritis with fibronectin deposits type 2.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Fibronectin glomerulopathy
FN1

References:

1.

Kornblihtt AR et al. (1984) Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain.

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2.

Sekiguchi K et al. (1986) Human liver fibronectin complementary DNAs: identification of two different messenger RNAs possibly encoding the alpha and beta subunits of plasma fibronectin.

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3.

Zneimer SM et al. (1988) Regional localization of the fibronectin and gamma crystallin genes to mouse chromosome 1 by in situ hybridization.

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4.

Prowse KR et al. (1986) Assignment of the human fibronectin structural gene to chromosome 2.

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5.

Gutman A et al. (1987) Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA.

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6.

Odermatt E et al. (1985) Repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation.

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7.

Jhanwar SC et al. (1986) In situ localization of human fibronectin (FN) genes to chromosome regions 2p14--p16, 2q34q36, and 11q12.1--q13.5 in germ line cells, but to chromosome 2 sites only in somatic cells.

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8.

Zardi L et al. (1979) Fibronectin: a chromatin-associated protein?

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9.

Eun CK et al. (1980) Human chromosome 11 affects the expression of fibronectin fibers in human x mouse cell hybrids.

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10.

Koch GA et al. (1982) Assignment of a fibronection gene to human chromosome 2 using monoclonal antibodies.

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11.

Niimi K et al. (2002) Fibronectin glomerulopathy with nephrotic syndrome in a 3-year-old male.

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12.

Kornblihtt AR et al. (1983) Isolation and characterization of cDNA clones for human and bovine fibronectins.

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13.

Hirano H et al. (1983) Isolation of genomic DNA clones spanning the entire fibronectin gene.

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14.

Kurkinen M et al. (1980) Polypeptides of human plasma fibronectin are similar but not identical.

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15.

None (1981) Fibronectin and its role in connective tissue diseases.

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16.

Rennard SI et al. (1981) Localization of the human fibronectin (FN) gene on chromosome 8 by a specific enzyme immunoassay.

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17.

None (1981) Fibronectin. A molecular glue.

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18.

Mosesson MW et al. (1980) The structure and biologic activities of plasma fibronectin.

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19.

Zardi L et al. (1982) Species-specific monoclonal antibodies in the assignment of the gene for human fibronectin to chromosome 2.

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20.

Wu BL et al. (1993) In situ hybridization applied to Waardenburg syndrome.

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21.

Skow LC et al. (1987) Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals.

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22.

Bing DH et al. (1982) Fibronectin binds to the C1q component of complement.

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23.

Mazzucco G et al. (1992) Glomerulonephritis with organized deposits: a mesangiopathic, not immune complex-mediated disease? A pathologic study of two cases in the same family.

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24.

Castelletti F et al. (2008) Mutations in FN1 cause glomerulopathy with fibronectin deposits.

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25.

Assmann KJ et al. (1995) Familial glomerulonephritis characterized by massive deposits of fibronectin.

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26.

Matsunaga T et al. (2003) Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia.

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27.

None (2000) Molecular switches in metastasis.

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28.

Clark EA et al. (2000) Genomic analysis of metastasis reveals an essential role for RhoC.

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29.

Bittner M et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling.

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30.

Sakai T et al. (2001) Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

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31.

Liao YF et al. (2002) The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.

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32.

Schwarz-Linek U et al. (2003) Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper.

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33.

Sakai T et al. (2003) Fibronectin requirement in branching morphogenesis.

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34.

Muro AF et al. (2003) Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan.

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35.

Jiang G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.

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36.

Grau S et al. (2006) The role of human HtrA1 in arthritic disease.

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37.

Owerbach D et al. (1978) Genetics of the large, external, transformation-sensitive (LETS) protein: assignment of a gene coding for expression of LETS to human chromosome 8.

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38.

Matsuura H et al. (1988) The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6. Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide.

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39.

Kornblihtt AR et al. (1985) Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

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40.

Orphanet article

Orphanet ID 159592 external link
41.

NCBI article

NCBI 2335 external link
42.

OMIM.ORG article

Omim 135600 external link
43.

Wikipedia article

Wikipedia EN (Fibronectin) external link
Update: Aug. 14, 2020
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