Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Insulin receptor substrate 2

The IRS2 gene encodes a protein that is an important component of signal transduction. It constitutes the link between various receptor tyrosine kinases and downstream effectors. For instance, it acts downstream of insulin receptor, IGF receptor, and diverse cytokin receptors. Mutations in this gene are associated with insulin resistance and type 2 diabetes mellitus.

Genetests:

Research Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Insulin resistance
CIDEC
Diabetes mellitus with insulin resistance and acanthosis nigricans
INSR
ENPP1
IRS1
IRS2
PPARG

References:

1.

Böhni R et al. (1999) Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

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2.

Taniguchi CM et al. (2005) Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.

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3.

Ogihara T et al. (1997) 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.

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4.

Terauchi Y et. al. (2007) Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

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5.

Shimomura I et al. (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.

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6.

Tobe K et al. (2001) Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.

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7.

Withers DJ et al. (1999) Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

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8.

Almind K et al. (1999) Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

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9.

Burks DJ et al. (2000) IRS-2 pathways integrate female reproduction and energy homeostasis.

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10.

Mammarella S et al. (2000) Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.

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11.

Kubota N et al. (2000) Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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12.

Wang H et al. (2001) New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.

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13.

Fritsche A et al. (2001) The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion.

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14.

D'Alfonso R et al. (2003) Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.

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15.

Lautier C et al. (2003) Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation.

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16.

Hennige AM et al. (2003) Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes.

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17.

Lin X et al. (2004) Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.

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18.

Uchida T et al. (2005) Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.

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19.

Taguchi A et al. (2007) Brain IRS2 signaling coordinates life span and nutrient homeostasis.

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20.

Selman C et al. (2008) Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".

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21.

Spiess CR et al. (2008) A victory for PETA.

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22.

Sun XJ et al. (1995) Role of IRS-2 in insulin and cytokine signalling.

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23.

Withers DJ et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice.

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Update: Sept. 26, 2018