Single-stranded DNA cytosine deaminase
The AICDA gene encodes a protein responsible for somatic hypermutation a key process in B lymphocyte maturation. Mutations cause autosomal recessive hyper-IgM syndrome 2.
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References:
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Prochnow C et al. (2007) The APOBEC-2 crystal structure and functional implications for the deaminase AID.
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Pefanis E et al. (2014) Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.
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Kumar R et al. (2013) AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.
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Péron S et al. (2012) AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells.
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Popp C et al. (2010) Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.
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6. |
Bhutani N et al. (2010) Reprogramming towards pluripotency requires AID-dependent DNA demethylation.
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7. |
Liu M et al. (2008) Two levels of protection for the B cell genome during somatic hypermutation.
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8. |
Pasqualucci L et al. (2008) AID is required for germinal center-derived lymphomagenesis.
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9. |
Matsumoto Y et al. (2007) Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
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10. |
Zarrin AA et al. (2007) Antibody class switching mediated by yeast endonuclease-generated DNA breaks.
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11. |
Durandy A et al. (2006) Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants.
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12. |
Ramiro AR et al. (2006) Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
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13. |
Basu U et al. (2005) The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.
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14. |
Ramiro AR et al. (2004) AID is required for c-myc/IgH chromosome translocations in vivo.
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15. |
Chaudhuri J et al. (2004) Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.
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16. |
Nambu Y et al. (2003) Transcription-coupled events associating with immunoglobulin switch region chromatin.
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17. |
Pham P et al. (2003) Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.
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18. |
Guo JU et al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.
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19. |
Revy P et al. (2000) Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
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20. |
Muramatsu M et al. (1999) Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
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21. |
Muto T et al. (2000) Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
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Muramatsu M et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
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23. |
Fagarasan S et al. (2001) In situ class switching and differentiation to IgA-producing cells in the gut lamina propria.
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24. |
Petersen S et al. (2001) AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
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Arakawa H et al. (2002) Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion.
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26. |
Okazaki IM et al. (2002) The AID enzyme induces class switch recombination in fibroblasts.
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27. |
Yoshikawa K et al. (2002) AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.
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28. |
Petersen-Mahrt SK et al. (2002) AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.
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Fagarasan S et al. (2002) Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.
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Chaudhuri J et al. (2003) Transcription-targeted DNA deamination by the AID antibody diversification enzyme.
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31. |
Ta VT et al. (2003) AID mutant analyses indicate requirement for class-switch-specific cofactors.
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Orphanet article
Orphanet ID 119554
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NCBI article
NCBI 57379
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OMIM.ORG article
Omim 605257
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Wikipedia article
Wikipedia EN (Activation-induced_cytidine_deaminase)
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Update: Aug. 14, 2020