Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

rho GTPase-activating protein 24

The ARHGAP24 gene encodes a GTPase regulation protein that is involved in actin remodeling. Genetic variations are reported in association with FSGS though it does not form a unique FSGS type yet.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Focal, segmental glomerulosclerosis (FSGS)
ALG13
ARHGAP24
CLU
Hereditary FSGS type 1
ACTN4
Hereditary FSGS type 2
TRPC6
Hereditary FSGS type 3
CD2AP
Hereditary FSGS type 4
APOL1
Hereditary FSGS type 5
INF2
Hereditary FSGS type 6
MYO1E
Hereditary FSGS type 7
PAX2
ITGA9
LAMA5
NXF5

References:

1.

Katoh M et. al. (2004) Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.

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2.

Su ZJ et. al. (2004) A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.

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3.

Lavelin I et. al. (2005) Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.

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4.

Ohta Y et. al. (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.

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5.

Akilesh S et. al. (2011) Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.

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6.

Ehrlicher AJ et. al. (2011) Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.

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Update: Sept. 26, 2018