rho GTPase-activating protein 24
The ARHGAP24 gene encodes a GTPase regulation protein that is involved in actin remodeling. Genetic variations are reported in association with FSGS though it does not form a unique FSGS type yet.
Genetests:
Related Diseases:
References:
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Katoh M et al. (2004) Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.
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Su ZJ et al. (2004) A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.
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3. |
Lavelin I et al. (2005) Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.
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4. |
Ohta Y et al. (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
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5. |
Akilesh S et al. (2011) Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.
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6. |
Ehrlicher AJ et al. (2011) Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
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7. |
NCBI article
NCBI 83478
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8. |
OMIM.ORG article
Omim 610586
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9. |
Orphanet article
Orphanet ID 285362
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10. |
Wikipedia article
Wikipedia EN (ARHGAP24)
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Update: Aug. 14, 2020