Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Complement receptor type 2

The CR2 gene encodes a complement receptor expressed on B lymphocytes which also binds Epstein-Barr virus. Mutations cause autosomal recessive variable immunodeficiency type 7 and susceptibility to lupus erythematodes.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Systemic lupus erythematosus susceptibility to 9
CR2
Variable immunodeficiency type 7
CR2

References:

1.

Rodriguez de Cordoba S et al. (1985) Human genes for three complement components that regulate the activation of C3 are tightly linked.

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2.

Weis JH et al. (1987) A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.

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3.

Fairweather D et al. (2006) Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart.

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4.

Wu H et al. (2007) Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

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5.

Thiel J et al. (2012) Genetic CD21 deficiency is associated with hypogammaglobulinemia.

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6.

Yefenof E et al. (1976) Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.

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7.

Moore MD et al. (1987) Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.

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8.

Rodriguez de Cordoba S et al. (1986) Quantitative variations of the C3b/C4b receptor (CR1) in human erythrocytes are controlled by genes within the regulator of complement activation (RCA) gene cluster.

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9.

Weis JJ et al. (1984) Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.

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10.

Szakonyi G et al. (2001) Structure of complement receptor 2 in complex with its C3d ligand.

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11.

Prota AE et al. (2002) The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

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12.

Asokan R et al. (2006) Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.

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13.

Barrington RA et al. (2009) Uncoupling CD21 and CD19 of the B-cell coreceptor.

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14.

Orphanet article

Orphanet ID 160142 [^]
15.

NCBI article

NCBI 1380 [^]
16.

OMIM.ORG article

Omim 120650 [^]
17.

Wikipedia article

Wikipedia EN (Complement_receptor_2) [^]
Update: April 29, 2019