Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

C5a anaphylatoxin chemotactic receptor 2

The C5AR2 gene encodes a G protein-coupled receptor that binds activated complement components such as C3a, C4a, and C5a. Therefor an involvement in immunological procesis is obvious. Moreover genetic variations have been associated with familial combined hyperlipidemia.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Combined familial hyperlipidemia with adipose tissue dysfunction
C5AR2
CREB3L3
LEPR
LIPE
PNPLA2
PPARG
USF1

References:

1.

Ohno M et al. (2000) A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.

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2.

Lee DK et al. (2001) Identification of four novel human G protein-coupled receptors expressed in the brain.

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3.

Cain SA et al. (2002) The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).

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4.

Kalant D et al. (2003) The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.

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5.

Okinaga S et al. (2003) C5L2, a nonsignaling C5A binding protein.

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6.

Huber-Lang M et al. (2005) Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.

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7.

Gerard NP et al. (2005) An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2.

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8.

Chen NJ et al. (2007) C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a.

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9.

Rittirsch D et al. (2008) Functional roles for C5a receptors in sepsis.

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10.

Wang R et al. (2013) Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis.

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11.

NCBI article

NCBI 27202 [^]
12.

OMIM.ORG article

Omim 609949 [^]
13.

Wikipedia article

Wikipedia EN (GPR77) [^]
Update: April 29, 2019