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Center for Nephrology and Metabolic Disorders
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Upstream stimulatory factor 1

This gene encodes a transcription factor which is involved in regulation of adipose tissue metabolism. Variations have been reported to be associated with familial combined hyperlipidemia.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Combined familial hyperlipidemia with adipose tissue dysfunction
C5AR2
CREB3L3
LEPR
LIPE
PNPLA2
PPARG
USF1
Combined familial hyperlipidemia with VLDL overproduction
APOE
GCKR
OSBPL10
USF1
Combined familial hyperlipidemia with dysfunctional VLDL metabolism
ANGPTL8
APOA1
APOA4
APOA5
APOC3
CETP
GALNT2
LCAT
LIPC
LIPG
LPL
RXRG
USF1

References:

1.

Putt W et al. (2004) Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.

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2.

van der Vleuten GM et al. (2007) The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia.

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3.

Lee JC et al. (2007) USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.

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4.

Huertas-Vazquez A et al. (2005) Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.

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5.

Wu S et al. (2010) Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice.

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6.

Naukkarinen J et al. (2005) USF1 and dyslipidemias: converging evidence for a functional intronic variant.

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7.

None (2004) USF1 on trial.

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8.

Yago M et al. (2002) Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase.

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9.

Zhong G et al. (2001) Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors.

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10.

Casado M et al. (1999) Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver.

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11.

Vallet VS et al. (1998) Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose.

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12.

None (1998) Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene.

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13.

Roy AL et al. (1997) Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1.

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14.

Viollet B et al. (1996) Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.

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15.

Steingrímsson E et al. (1995) Murine chromosomal location of five bHLH-Zip transcription factor genes.

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16.

Shieh BH et al. (1993) Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23.

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17.

Sirito M et al. (1994) Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells.

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18.

Lefrançois-Martinez AM et al. (1995) Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.

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19.

Henrion AA et al. (1995) Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse.

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20.

Gregor PD et al. (1990) The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

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21.

Coon H et al. (2005) Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides.

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22.

Pajukanta P et al. (2004) Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

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23.

NCBI article

NCBI 7391 external link
24.

OMIM.ORG article

Omim 191523 external link
25.

Wikipedia article

Wikipedia EN (USF1) external link
Update: Aug. 14, 2020
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