Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Multidrug resistance protein 1

Das ABCB1 gene encodes a transport protein variations have been reported to alter metabolism of several drugs. An association of genetic variations is seen with inflammatory bowel disease.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Inflammatory bowel disease 13
ABCB1

References:

1.

Panwala CM et al. (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis.

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2.

Brant SR et al. (2003) MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

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3.

Ho GT et al. (2006) ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.

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4.

de Lannoy IA et al. (1992) The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

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5.

Trezise AE et al. (1992) The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

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6.

Chan HS et al. (1991) P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma.

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7.

Safa AR et al. (1990) Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

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8.

Taylor HR et al. (1990) Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection.

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9.

Kartner N et al. () Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.

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10.

Fojo AT et al. (1987) Expression of a multidrug-resistance gene in human tumors and tissues.

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11.

Ruiz JC et al. (1989) Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

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12.

Riordan JR et al. () Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

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13.

Chen CJ et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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14.

Bell DR et al. (1987) Chromosomal location of human P-glycoprotein gene sequences.

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15.

Ueda K et al. (1986) The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.

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16.

Trent JM et al. (1987) Clarification of the chromosomal assignment of the human P-glycoprotein/mdr1 gene: possible coincidence with the cystic fibrosis and c-met oncogene.

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17.

Martinsson T et al. (1987) Localization of the multidrug resistance-associated 170 kDa P-glycoprotein gene to mouse chromosome 5 and to homogeneously staining regions in multidrug-resistant mouse cells by in situ hybridization.

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18.

Ueda K et al. (1987) Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

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19.

Choi KH et al. (1988) An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

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20.

Fojo A et al. (1986) Localization of multidrug resistance-associated DNA sequences to human chromosome 7.

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21.

Gros P et al. () Isolation and expression of a complementary DNA that confers multidrug resistance.

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22.

Ueda K et al. (1987) The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

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23.

Croop JM et al. (1988) Genetics of multidrug resistance.

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24.

Shen DW et al. (1986) Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

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25.

Roninson IB et al. (1986) Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

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26.

Ueda K et al. (1987) Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

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27.

Callen DF et al. (1987) Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.

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28.

Pastan I et al. (1987) Multiple-drug resistance in human cancer.

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29.

Slovak ML et al. (1987) Cytogenetic alterations associated with the acquisition of doxorubicin resistance: possible significance of chromosome 7 alterations.

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30.

Gros P et al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins.

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31.

Baldini N et al. (1995) Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.

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32.

Schinkel AH et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

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33.

van Helvoort A et al. (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

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34.

Mickley LA et al. (1997) Gene rearrangement: a novel mechanism for MDR-1 gene activation.

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35.

Kim RB et al. (1998) The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

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36.

Randolph GJ et al. (1998) A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels.

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37.

Lankas GR et al. () Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

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38.

Smit JW et al. (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.

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39.

Hoffmeyer S et al. (2000) Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

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40.

Synold TW et al. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.

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41.

Schaeffeler E et al. (2001) Frequency of C3435T polymorphism of MDR1 gene in African people.

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42.

Mealey KL et al. (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

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43.

Siddiqui A et al. (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

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44.

Tang K et al. (2004) Genomic evidence for recent positive selection at the human MDR1 gene locus.

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45.

Neff MW et al. (2004) Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.

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46.

Zimprich F et al. (2004) Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy.

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47.

Tan NC et al. (2004) Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.

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48.

Tate SK et al. (2005) Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.

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49.

Dong J et al. (2005) Structural basis of energy transduction in the transport cycle of MsbA.

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50.

Wang YC et al. (2006) Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.

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51.

Dawson RJ et al. (2006) Structure of a bacterial multidrug ABC transporter.

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52.

Kimchi-Sarfaty C et al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity.

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53.

Sims-Mourtada J et al. (2007) Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport.

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54.

Aller SG et al. (2009) Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

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55.

Bao L et al. (2012) Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.

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56.

Katayama K et al. (2014) Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

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57.

NCBI article

NCBI 5243 [^]
58.

OMIM.ORG article

Omim 171050 [^]
59.

Wikipedia article

Wikipedia EN (P-glycoprotein) [^]
Update: April 29, 2019