Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Multidrug resistance protein 1

Das ABCB1 gene encodes a transport protein variations have been reported to alter metabolism of several drugs. An association of genetic variations is seen with inflammatory bowel disease.

Genetests:

Research Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Inflammatory bowel disease 13
ABCB1

References:

1.

de Lannoy IA et. al. (1992) The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

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2.

Trezise AE et. al. (1992) The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

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3.

Chan HS et. al. (1991) P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma.

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4.

Safa AR et. al. (1990) Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

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5.

Taylor HR et. al. (1990) Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection.

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6.

Kartner N et. al. () Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.

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7.

Fojo AT et. al. (1987) Expression of a multidrug-resistance gene in human tumors and tissues.

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8.

Ruiz JC et. al. (1989) Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

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9.

Riordan JR et. al. () Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

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10.

Chen CJ et. al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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11.

Bell DR et. al. (1987) Chromosomal location of human P-glycoprotein gene sequences.

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12.

Ueda K et. al. (1986) The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.

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13.

Trent JM et. al. (1987) Clarification of the chromosomal assignment of the human P-glycoprotein/mdr1 gene: possible coincidence with the cystic fibrosis and c-met oncogene.

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14.

Martinsson T et. al. (1987) Localization of the multidrug resistance-associated 170 kDa P-glycoprotein gene to mouse chromosome 5 and to homogeneously staining regions in multidrug-resistant mouse cells by in situ hybridization.

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15.

Ueda K et. al. (1987) Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

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16.

Choi KH et. al. (1988) An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

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17.

Fojo A et. al. (1986) Localization of multidrug resistance-associated DNA sequences to human chromosome 7.

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18.

Gros P et. al. () Isolation and expression of a complementary DNA that confers multidrug resistance.

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19.

Ueda K et. al. (1987) The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

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20.

Croop JM et. al. (1988) Genetics of multidrug resistance.

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21.

Shen DW et. al. (1986) Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

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22.

Roninson IB et. al. (1986) Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

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23.

Ueda K et. al. (1987) Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

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24.

Callen DF et. al. (1987) Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.

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25.

Pastan I et. al. (1987) Multiple-drug resistance in human cancer.

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26.

Slovak ML et. al. (1987) Cytogenetic alterations associated with the acquisition of doxorubicin resistance: possible significance of chromosome 7 alterations.

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27.

Gros P et. al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins.

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28.

Baldini N et. al. (1995) Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.

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29.

Schinkel AH et. al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

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30.

van Helvoort A et. al. (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

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31.

Mickley LA et. al. (1997) Gene rearrangement: a novel mechanism for MDR-1 gene activation.

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32.

Kim RB et. al. (1998) The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

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33.

Randolph GJ et. al. (1998) A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels.

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34.

Lankas GR et. al. () Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

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35.

Panwala CM et. al. (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis.

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36.

Smit JW et. al. (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.

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37.

Hoffmeyer S et. al. (2000) Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

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38.

Synold TW et. al. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux.

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39.

Schaeffeler E et. al. (2001) Frequency of C3435T polymorphism of MDR1 gene in African people.

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40.

Mealey KL et. al. (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

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41.

Siddiqui A et. al. (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.

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42.

Brant SR et. al. (2003) MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

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43.

Tang K et. al. (2004) Genomic evidence for recent positive selection at the human MDR1 gene locus.

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44.

Neff MW et. al. (2004) Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.

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45.

Zimprich F et. al. (2004) Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy.

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46.

Tan NC et. al. (2004) Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy.

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47.

Tate SK et al. (2005) Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin.

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48.

Dong J et. al. (2005) Structural basis of energy transduction in the transport cycle of MsbA.

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49.

Wang YC et. al. (2006) Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.

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50.

Ho GT et. al. (2006) ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.

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51.

Dawson RJ et. al. (2006) Structure of a bacterial multidrug ABC transporter.

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52.

Kimchi-Sarfaty C et. al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity.

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53.

Sims-Mourtada J et. al. (2007) Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport.

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54.

Aller SG et. al. (2009) Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

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55.

Bao L et. al. (2012) Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.

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56.

Katayama K et. al. (2014) Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

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Update: Sept. 26, 2018