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ATP-binding cassette sub-family G member 2

The ABCG2 gene encodes a transport protein that is involved in metabolism of several drugs. Also it is reported to be involved in the development of gout and hyperurecemia.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Gout susceptibility 1
ABCG2

References:

1.

Dehghan A et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.

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2.

Zelinski T et al. (2012) ABCG2 null alleles define the Jr(a-) blood group phenotype.

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3.

Saison C et al. (2012) Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior.

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4.

Wang F et al. (2010) hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations.

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5.

Woodward OM et al. (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.

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6.

Maekawa K et al. (2006) Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.

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7.

Jonker JW et al. (2005) The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

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8.

Krishnamurthy P et al. (2004) The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.

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9.

Jonker JW et al. (2002) The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

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10.

Ozvegy C et al. (2002) Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.

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11.

Eisenblätter T et al. (2002) A new multidrug resistance protein at the blood-brain barrier.

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12.

Bailey-Dell KJ et al. (2001) Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene.

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13.

Ozvegy C et al. (2001) Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

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14.

Miyake K et al. (1999) Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

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15.

Doyle LA et al. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells.

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16.

Allikmets R et al. (1998) A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

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17.

Matsuo H et al. (2009) Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

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18.

Sims-Mourtada J et al. (2007) Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport.

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19.

NCBI article

NCBI 9429 external link
20.

OMIM.ORG article

Omim 603756 external link
21.

Wikipedia article

Wikipedia EN (ABCG2) external link
Update: Aug. 14, 2020
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