Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Angiopoietin-related protein 4

The ANGPTL4 gene encodes a glycosylated plasma hormone which is involved in regulation of glucose homeostasis, lipid metabolism, and insulin sensitivity. Mutations cause familial Hypertrigyceridemia.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Plasma triglyceride level quantitative trait locus
ANGPTL4

References:

1.

Cefalù AB et. al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.

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2.

Zheng J et. al. (2012) Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.

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3.

Kersten S et. al. (2000) Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene.

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4.

Yoon JC et. al. (2000) Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.

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5.

Bäckhed F et. al. (2004) The gut microbiota as an environmental factor that regulates fat storage.

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6.

Minn AJ et. al. (2005) Genes that mediate breast cancer metastasis to lung.

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7.

Sukonina V et. al. (2006) Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue.

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8.

Galaup A et. al. (2006) Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness.

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9.

Romeo S et. al. (2007) Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

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10.

Padua D et. al. (2008) TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.

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11.

Talmud PJ et. al. (2008) ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

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12.

Romeo S et. al. (2009) Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

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13.

Yin W et. al. (2009) Genetic variation in ANGPTL4 provides insights into protein processing and function.

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14.

Dewey FE et. al. (2016) Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

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Update: Sept. 26, 2018