Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Fibroblast growth factor receptor 4

The FGFR4 gene encodes an FGF receptor. Interaction of that receptor with tumor progression is assumed.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Keegan K et. al. (1991) Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

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2.

Avraham KB et. al. (1994) Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.

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3.

Warrington JA et. al. (1992) A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5.

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4.

Armstrong E et. al. (1992) Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.

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5.

Vainikka S et. al. (1992) Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.

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6.

Partanen J et. al. (1991) FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

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7.

Holtrich U et. al. (1991) Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

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8.

Kostrzewa M et. al. (1998) Genomic structure and complete sequence of the human FGFR4 gene.

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9.

Jung J et. al. (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors.

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10.

Bange J et. al. (2002) Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.

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11.

Taylor JG et. al. (2009) Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

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Update: Sept. 26, 2018