Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

beta-Klotho

The KLB gene encodes a cDNA quite similar to klotho. Therefore a similar function or interaction can be hypothesized.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Ito S et al. (2000) Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

external link
2.

Ito S et al. (2005) Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.

external link
3.

Ogawa Y et al. (2007) BetaKlotho is required for metabolic activity of fibroblast growth factor 21.

external link
4.

NCBI article

NCBI 152831 external link
5.

OMIM.ORG article

Omim 611135 external link
Update: Aug. 14, 2020
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