Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Serine/threonine-protein kinase Sgk1

The SGK1 gene encodes a protein kinase which plays an important role in cellular stress response. An association with certain conditions such as hypertension and diabetes is proposed.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Webster MK et al. (1993) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

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2.

Waldegger S et al. (1997) Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.

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3.

Waldegger S et al. (1998) Genomic organization and chromosomal localization of the human SGK protein kinase gene.

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4.

Kobayashi T et al. (1999) Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.

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5.

Park J et al. (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.

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6.

Lang F et al. (2000) Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.

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7.

Mikosz CA et al. (2001) Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1.

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8.

Tsai KJ et al. (2002) sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats.

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9.

Arteaga MF et al. (2006) An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery.

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10.

Arteaga MF et al. (2008) A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons.

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11.

Salker MS et al. (2011) Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.

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12.

Wu C et al. (2013) Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.

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13.

Kleinewietfeld M et al. (2013) Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.

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14.

NCBI article

NCBI 6446 [^]
15.

OMIM.ORG article

Omim 602958 [^]
16.

Wikipedia article

Wikipedia EN (SGK1) [^]
Update: April 29, 2019