Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Intraflagellar transport protein 74 homolog

The IFT74 gene encodes an intraflaggelar transport protein. It is responsible for autosomal recessive Bardet-Biedl syndrome 20.


Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Bardet-Biedl syndrome 20



Bhogaraju S et. al. (2013) Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.


Bell SE et. al. (2001) Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.


Ezratty EJ et. al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.


Lindstrand A et. al. (2016) Copy-Number Variation Contributes to the Mutational Load of Bardet-Biedl Syndrome.

Update: Sept. 26, 2018