Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Protein sprouty homolog 2

The SPRY2 gene encodes a protein that is involved in various signal transduction processes. Mutations cause autosomal dominant IgA nephropathy type 3.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

IgA nephropathy type 3
SPRY2

References:

1.

Milillo A et al. (2015) A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy.

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2.

Hacohen N et al. (1998) sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

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3.

Lim J et al. (2000) Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.

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4.

Gross I et al. (2001) Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation.

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5.

Yusoff P et al. (2002) Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

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6.

Egan JE et al. (2002) The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.

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7.

Lim J et al. (2002) The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.

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8.

Hanafusa H et al. (2002) Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

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9.

Ding W et al. (2003) Functional analysis of the human Sprouty2 gene promoter.

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10.

Shim K et al. (2005) Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling.

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11.

Taketomi T et al. (2005) Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.

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12.

Klein OD et al. (2006) Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.

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13.

Metzger RJ et al. (2008) The branching programme of mouse lung development.

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14.

Tang N et al. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.

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15.

NCBI article

NCBI 10253 [^]
16.

OMIM.ORG article

Omim 602466 [^]
17.

Wikipedia article

Wikipedia EN (SPRY2) [^]
Update: April 29, 2019