Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

C-X-C chemokine receptor type 1

The CXCR1 gene encodes a chemokine receptor for interleukin 8. Genetic variations influence susceptibility to HIV infections and disease progression. Also in animal models a mesangioproliferative glomerulonephritis was observed.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

HIV resistance
CCR5
CXCR1
HIV1 susceptibility
IL10
Mesangioproliferative glomerulonephritis
CXCR1
Complement component C1q deficiency
C1QA
C1QB
C1QC
IgA nephropathy
CFHR1
CFHR3
CFHR5
IgA nephropathy type 1
IgA nephropathy type 2
IgA nephropathy type 3
SPRY2
Schimke Immunoosseous dysplasia
SMARCAL1
Wiskott–Aldrich syndrome
WAS

References:

1.

Morris SW et al. (1992) Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.

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2.

Holmes WE et al. (1991) Structure and functional expression of a human interleukin-8 receptor.

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3.

Mollereau C et al. (1993) The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor.

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4.

Lloyd A et al. (1993) Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35.

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5.

Palter SF et al. (2001) Interleukin-8 in the human fallopian tube.

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6.

Weathington NM et al. (2006) A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.

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7.

Vasilescu A et. al. (2007) A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.

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8.

Hartl D et al. (2007) Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease.

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9.

Ozaltin F et al. (2013) Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.

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10.

NCBI article

NCBI 3577 [^]
11.

OMIM.ORG article

Omim 146929 [^]
12.

Wikipedia article

Wikipedia EN (Interleukin_8_receptor,_alpha) [^]
Update: April 29, 2019