Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Enzyme APOBEC-1

The APOBEC1 gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

References:

1.

Hodges P et. al. (1992) Apolipoprotein B mRNA editing: a new tier for the control of gene expression.

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2.

Yamanaka S et. al. (1995) Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

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3.

Espinosa R et. al. (1994) Assignment of the gene encoding the human apolipoprotein B mRNA editing enzyme (APOBEC1) to chromosome 12p13.1.

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4.

Navaratnam N et. al. (1995) Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site.

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5.

Lau PP et. al. (1994) Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.

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6.

Hadjiagapiou C et. al. (1994) Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein.

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7.

Betts L et. al. (1994) Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex.

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8.

None (1993) RNA editing: exploring one mode with apolipoprotein B mRNA.

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9.

Morrison JR et. al. (1996) Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.

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10.

Oka K et. al. (1997) Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice.

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11.

Hirano K et. al. (1997) Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide.

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12.

Mukhopadhyay D et. al. (2002) C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.

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13.

Harris RS et. al. (2002) RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

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14.

Guo JU et. al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

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15.

Roberts SA et. al. (2013) An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

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Update: Sept. 26, 2018