Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Enzyme APOBEC-2

The APOBEC2 gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

References:

1.

Liao W et al. (1999) APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family.

external link
2.

Prochnow C et al. (2007) The APOBEC-2 crystal structure and functional implications for the deaminase AID.

external link
3.

Sato Y et al. (2010) Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy.

external link
4.

NCBI article

NCBI 10930 external link
5.

OMIM.ORG article

Omim 604797 external link
6.

Wikipedia article

Wikipedia EN (APOBEC2) external link
Update: Aug. 14, 2020
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