Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The APOBEC2 gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
Disorders of mRNA editing
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APOBEC1
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APOBEC2
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APOBEC3A
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APOBEC3B
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APOBEC3C
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APOBEC3D
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APOBEC3F
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APOBEC3G
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APOBEC3H
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APOBEC4
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| 1. |
Liao W et al. (1999) APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. 
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| 2. |
Prochnow C et al. (2007) The APOBEC-2 crystal structure and functional implications for the deaminase AID.
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| 3. |
Sato Y et al. (2010) Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy.
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| 4. |
NCBI article NCBI 10930
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| 5. |
OMIM.ORG article Omim 604797
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| 6. |
Wikipedia article Wikipedia EN (APOBEC2)
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