Enzyme APOBEC-3B
The APOBEC3B gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.
Genetests:
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
Related Diseases:
Disorders of mRNA editing
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APOBEC1
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APOBEC2
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APOBEC3A
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APOBEC3B
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APOBEC3C
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APOBEC3D
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APOBEC3F
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APOBEC3G
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APOBEC3H
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APOBEC4
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References:
| 1. |
Madsen P et al. (1999) Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. [^] |
| 2. |
Jarmuz A et al. (2002) An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. [^] |
| 3. |
Bogerd HP et al. (2006) Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. [^] |
| 4. |
Burns MB et al. (2013) APOBEC3B is an enzymatic source of mutation in breast cancer. [^] |
| 5. |
Burns MB et al. (2013) Evidence for APOBEC3B mutagenesis in multiple human cancers. [^] |
| 6. |
Marchetto MC et al. (2013) Differential L1 regulation in pluripotent stem cells of humans and apes. [^] |
| 7. |
NCBI article NCBI 9582 [^] |
| 8. |
OMIM.ORG article Omim 607110 [^] |
| 9. |
Wikipedia article Wikipedia EN (APOBEC3B) [^] |
