Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Enzyme APOBEC-3B

The APOBEC3B gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

References:

1.

Madsen P et. al. (1999) Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.

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2.

Jarmuz A et. al. (2002) An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

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3.

Bogerd HP et. al. (2006) Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.

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4.

Burns MB et. al. (2013) APOBEC3B is an enzymatic source of mutation in breast cancer.

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5.

Burns MB et. al. (2013) Evidence for APOBEC3B mutagenesis in multiple human cancers.

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6.

Marchetto MC et. al. (2013) Differential L1 regulation in pluripotent stem cells of humans and apes.

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Update: Sept. 26, 2018