Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Enzyme APOBEC-3C

The APOBEC3C gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

References:

1.

Harris RS et al. (2002) RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

external link
2.

Vartanian JP et al. (2008) Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.

external link
3.

Jarmuz A et al. (2002) An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

external link
4.

Stauch B et al. (2009) Model structure of APOBEC3C reveals a binding pocket modulating ribonucleic acid interaction required for encapsidation.

external link
5.

NCBI article

NCBI 27350 external link
6.

OMIM.ORG article

Omim 607750 external link
7.

Wikipedia article

Wikipedia EN (APOBEC3C) external link
Update: Aug. 14, 2020
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