Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Enzyme APOBEC-3F

The APOBEC3F gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

References:

1.

Jarmuz A et. al. (2002) An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

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2.

Wiegand HL et. al. (2004) A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins.

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Update: Sept. 26, 2018