Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Enzyme APOBEC-3H

The APOBEC3H gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Disorders of mRNA editing
APOBEC1
APOBEC2
APOBEC3A
APOBEC3B
APOBEC3C
APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H
APOBEC4

References:

1.

Vartanian JP et al. (2008) Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.

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2.

OhAinle M et al. (2006) Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H.

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3.

Wedekind JE et al. (2003) Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.

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4.

NCBI article

NCBI 164668 [^]
5.

OMIM.ORG article

Omim 610976 [^]
6.

Wikipedia article

Wikipedia EN (APOBEC3H) [^]
Update: April 29, 2019