Enzyme APOBEC-3H
The APOBEC3H gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.
Genetests:
| Clinic | Method | Carrier testing |
| Turnaround | 5 | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 | |
| Specimen type | genomic DNA |
Related Diseases:
Disorders of mRNA editing
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APOBEC1
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APOBEC2
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APOBEC3A
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APOBEC3B
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APOBEC3C
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APOBEC3D
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APOBEC3F
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APOBEC3G
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APOBEC3H
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APOBEC4
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References:
| 1. |
Vartanian JP et. al. (2008) Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions. [^] |
| 2. |
Wedekind JE et. al. (2003) Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. [^] |
| 3. |
OhAinle M et. al. (2006) Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H. [^] |
Update: Sept. 26, 2018
