Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Protein Z-dependent protease inhibitor

The SERPINA10 gene encodes a proteinase inhibitor which with its cofactor protein Z inhibits activated coagulations factors Xa and XIa. Inactivating mutations may promote thrombophilia.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Protein Z deficiency
PROZ
SERPINA10

References:

1.

Yin ZF et al. (2000) Prothrombotic phenotype of protein Z deficiency.

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2.

Han X et al. (1998) Isolation of a protein Z-dependent plasma protease inhibitor.

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3.

New L et al. (1996) cDNA cloning of rasp-1, a novel gene encoding a plasma protein associated with liver regeneration.

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4.

Han X et al. (1999) The protein Z-dependent protease inhibitor is a serpin.

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5.

Van de Water N et al. (2004) Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia.

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6.

NCBI article

NCBI 51156 [^]
7.

OMIM.ORG article

Omim 605271 [^]
8.

Wikipedia article

Wikipedia EN (Protein_Z-related_protease_inhibitor) [^]
Update: April 29, 2019