ATP-binding cassette sub-family G member 1
The ABCG1 gene encodes an ATP dependend membrane transport protein involved in cholesterol and phospholipid transport. Epigenetic modification of this gene was associated with dyslipidemia.
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References:
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Braun KV et al. (2016) The role of DNA methylation in dyslipidaemia: A systematic review.
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Pfeiffer L et al. (2015) DNA methylation of lipid-related genes affects blood lipid levels.
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3. |
Guay SP et al. (2014) Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia.
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4. |
Yvan-Charvet L et al. (2010) ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation.
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5. |
Chen H et al. (1996) Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.
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6. |
Savary S et al. (1996) Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene.
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7. |
Croop JM et al. (1997) Isolation and characterization of a mammalian homolog of the Drosophila white gene.
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8. |
Klucken J et al. (2000) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.
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9. |
Langmann T et al. (2000) Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene.
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10. |
Lorkowski S et al. (2001) Genomic sequence and structure of the human ABCG1 (ABC8) gene.
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11. |
Jakobsson T et al. (2009) GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.
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12. |
Peng P et al. (2014) A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease.
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13. |
NCBI article
NCBI 9619
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14. |
OMIM.ORG article
Omim 603076
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15. |
Wikipedia article
Wikipedia EN (ABCG1)
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Update: Aug. 14, 2020