Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Micro RNA miRNA33B

The MIR33B gene encodes a micro-RNA that is not translated but involved in gene regulation. Epigenetic modification of this gene was associated with dyslipidemia.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Epigenetic dyslipidemia
ABCG1
CPT1A
MIR33B
SREBF1
TNIP1
TNNT1

References:

1.

Najafi-Shoushtari SH et al. (2010) MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.

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2.

Braun KV et al. (2016) The role of DNA methylation in dyslipidaemia: A systematic review.

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3.

Pfeiffer L et al. (2015) DNA methylation of lipid-related genes affects blood lipid levels.

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4.

Rayner KJ et al. (2011) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

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5.

Griffiths-Jones S et al. (2006) miRBase: microRNA sequences, targets and gene nomenclature.

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6.

Brown MS et al. (2010) Medicine. HDL miR-ed down by SREBP introns.

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7.

NCBI article

NCBI 693120 [^]
8.

OMIM.ORG article

Omim 613486 [^]
Update: April 29, 2019