Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Micro RNA miRNA33B

The MIR33B gene encodes a micro-RNA that is not translated but involved in gene regulation. Epigenetic modification of this gene was associated with dyslipidemia.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Research Method Methylation test
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Epigenetic dyslipidemia
ABCG1
CPT1A
MIR33B
SREBF1
TNIP1
TNNT1

References:

1.

Najafi-Shoushtari SH et. al. (2010) MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.

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2.

Braun KV et. al. (2016) The role of DNA methylation in dyslipidaemia: A systematic review.

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3.

Pfeiffer L et. al. (2015) DNA methylation of lipid-related genes affects blood lipid levels.

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4.

Rayner KJ et. al. (2011) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

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5.

Griffiths-Jones S et. al. (2006) miRBase: microRNA sequences, targets and gene nomenclature.

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6.

Brown MS et. al. (2010) Medicine. HDL miR-ed down by SREBP introns.

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Update: Sept. 26, 2018