Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

TNFAIP3-interacting protein 1

The TNIP1 gene encodes a protein that is involved in transcription control. Mutations are found in autoimmune diseases such as psoriatric and rheumatoid arthritis and lupus erythematodes. Epigenetic modification of this gene was associated with dyslipidemia.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Research Method Methylation test
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Epigenetic dyslipidemia
ABCG1
CPT1A
MIR33B
SREBF1
TNIP1
TNNT1

References:

1.

Braun KV et. al. (2016) The role of DNA methylation in dyslipidaemia: A systematic review.

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2.

Pfeiffer L et. al. (2015) DNA methylation of lipid-related genes affects blood lipid levels.

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3.

Fukushi M et. al. (1999) Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression.

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4.

Zhang S et. al. (2002) A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling.

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5.

El Bakkouri K et. al. (2005) Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model.

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6.

Oshima S et. al. (2009) ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.

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7.

Gurevich I et. al. (2009) Liganded RARalpha and RARgamma interact with but are repressed by TNIP1.

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Update: Sept. 26, 2018