Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Syndecan-3

The SDC3 gene encodes a protein of the cytoskeleton which is involved in signal transduction. Mutations can cause obesity wich follows a dominant model. Also synergistic effects with mutations in other genes have to be taken into account.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Susceptibility to obesity
ADRB2
ADRB3
CARTPT
ENPP1
GHRL
PPARGC1B
SDC3
UCP1

References:

1.

Carey DJ et. al. (1992) Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan.

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2.

Spring J et. al. (1994) Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family.

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3.

Reizes O et. al. (2001) Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3.

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4.

Bobardt MD et. al. (2003) Syndecan captures, protects, and transmits HIV to T lymphocytes.

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5.

Cornelison DD et. al. (2004) Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.

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6.

Strader AD et. al. (2004) Mice lacking the syndecan-3 gene are resistant to diet-induced obesity.

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7.

Ha E et. al. (2006) Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the Korean population.

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8.

de Witte L et. al. (2007) Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.

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Update: Sept. 26, 2018