Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Beta-3 adrenergic receptor

The ADRB3 encodes the beta-3-adrenergic receptor. Mutations can cause obesity wich follows a dominant model. Also synergistic effects with mutations in other genes have to be taken into account.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Susceptibility to obesity
ADRB2
ADRB3
CARTPT
ENPP1
GHRL
PPARGC1B
SDC3
UCP1

References:

1.

Bachman ES et. al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance.

[^]
2.

Cagliani R et. al. (2009) Diverse evolutionary histories for beta-adrenoreceptor genes in humans.

[^]
3.

Emorine LJ et. al. (1989) Molecular characterization of the human beta 3-adrenergic receptor.

[^]
4.

Walston J et. al. (1995) Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene.

[^]
5.

Clément K et. al. (1995) Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

[^]
6.

Wilkie TM et. al. (1993) Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.

[^]
7.

van Spronsen A et. al. (1993) The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.

[^]
8.

Gagnon J et. al. (1996) The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.

[^]
9.

Elbein SC et. al. (1996) Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair.

[^]
10.

Comuzzie AG et. al. (1997) A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2.

[^]
11.

Nagase T et. al. (1997) Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis.

[^]
12.

Kim-Motoyama H et. al. (1997) A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride.

[^]
13.

Mitchell BD et. al. (1998) A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.

[^]
14.

Büettner R et. al. (1998) The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.

[^]
15.

García-Rubi E et. al. (1998) Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women.

[^]
16.

Hoffstedt J et. al. (1999) Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.

[^]
17.

Shihara N et. al. (1999) The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity.

[^]
18.

Festa A et. al. (1999) Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitus.

[^]
19.

Urhammer SA et. al. (2000) Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects.

[^]
20.

Walston J et. al. (2000) Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.

[^]
21.

Wang X et. al. (2004) Effects of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates.

[^]
Update: Sept. 26, 2018