Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Agouti-related protein

The AGRP gene encodes a protein that is involved in signal transduction from melanocortin-3 and melanocortin-4 receptors. Mutations cause autosomal dominant late onset obesity or leanness.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Inherited leanness
AGRP
Late-onset obesity
AGRP

References:

1.

Kitamura T et. al. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

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2.

Shutter JR et. al. (1997) Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

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3.

Ollmann MM et. al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.

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4.

Graham M et. al. (1997) Overexpression of Agrt leads to obesity in transgenic mice.

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5.

Katsuki A et. al. (2001) Plasma levels of agouti-related protein are increased in obese men.

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6.

Brown AM et. al. (2001) The gene structure and minimal promoter of the human agouti related protein.

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7.

Argyropoulos G et. al. (2002) A polymorphism in the human agouti-related protein is associated with late-onset obesity.

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8.

Marks DL et. al. (2004) Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.

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9.

Luquet S et. al. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.

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10.

Andrews ZB et. al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

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11.

Atasoy D et. al. (2012) Deconstruction of a neural circuit for hunger.

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12.

Krashes MJ et. al. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

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Update: Sept. 26, 2018