Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Fibroblast growth factor 8

The FGF8 gene encodes an androgen-induced growth factor. Mutations cause autosomal recessive or dominant hypogonadotropic hypogonadism 6 with or without anosmia.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Hypogonadotropic hypogonadism 6 with or without anosmia
FGF8

References:

1.

Johnson RL et. al. (1997) Molecular models for vertebrate limb development.

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2.

Thomas BL et. al. (2000) Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch.

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3.

Copeland NG et. al. (1993) A genetic linkage map of the mouse: current applications and future prospects.

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4.

Riley BM et. al. (2007) Impaired FGF signaling contributes to cleft lip and palate.

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5.

Jung J et. al. (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors.

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6.

Falardeau J et. al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice.

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7.

Neugebauer JM et. al. (2009) FGF signalling during embryo development regulates cilia length in diverse epithelia.

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8.

Tanaka A et. al. (1995) Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties.

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9.

Mattei MG et. al. (1995) Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively.

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10.

Lorenzi MV et. al. (1995) Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8.

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11.

White RA et. al. (1995) Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region.

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12.

Gemel J et. al. (1996) Structure and sequence of human FGF8.

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13.

Payson RA et. al. (1996) The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.

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14.

Ghosh AK et. al. (1996) Molecular cloning and characterization of human FGF8 alternative messenger RNA forms.

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15.

Yoshiura K et. al. (1997) Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes.

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16.

Meyers EN et. al. (1998) An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination.

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17.

Meyers EN et. al. (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.

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18.

Sun X et. al. (1999) Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.

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19.

Sun X et. al. (2000) Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development.

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20.

Streit A et. al. (2000) Initiation of neural induction by FGF signalling before gastrulation.

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21.

Moon AM et. al. (2000) Fgf8 is required for outgrowth and patterning of the limbs.

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22.

Lewandoski M et. al. (2000) Fgf8 signalling from the AER is essential for normal limb development.

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23.

Dubrulle J et. al. (2001) FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation.

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24.

Fukuchi-Shimogori T et. al. (2001) Neocortex patterning by the secreted signaling molecule FGF8.

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25.

Trainor PA et. al. (2002) Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.

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26.

Zammit C et. al. (2002) Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer.

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27.

Sun X et. al. (2002) Functions of FGF signalling from the apical ectodermal ridge in limb development.

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28.

Dudley AT et. al. (2002) A re-examination of proximodistal patterning during vertebrate limb development.

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29.

Storm EE et. al. (2003) Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain.

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30.

Gunhaga L et. al. (2003) Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.

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31.

Fukuchi-Shimogori T et. al. (2003) Emx2 patterns the neocortex by regulating FGF positional signaling.

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32.

Dubrulle J et. al. (2004) fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo.

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33.

Ladher RK et. al. (2005) FGF8 initiates inner ear induction in chick and mouse.

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34.

Martinez-Morales JR et. al. (2005) Differentiation of the vertebrate retina is coordinated by an FGF signaling center.

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35.

Tanaka Y et. al. (2005) FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.

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36.

Olsen SK et. al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.

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37.

Mariani FV et. al. (2008) Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning.

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38.

Verheyden JM et. al. (2008) An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.

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39.

Yu SR et. al. (2009) Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules.

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40.

Watanabe Y et. al. (2010) Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.

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41.

Arauz RF et. al. (2010) A Hypomorphic Allele in the FGF8 Gene Contributes to Holoprosencephaly and Is Allelic to Gonadotropin-Releasing Hormone Deficiency in Humans.

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42.

Nowak M et. al. (2011) Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking.

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43.

Naiche LA et. al. (2011) FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.

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44.

Cooper KL et. al. (2011) Initiation of proximal-distal patterning in the vertebrate limb by signals and growth.

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45.

Roselló-Díez A et. al. (2011) Diffusible signals, not autonomous mechanisms, determine the main proximodistal limb subdivision.

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46.

Boulet AM et. al. (2012) Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo.

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47.

Nacu E et. al. (2016) FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration.

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Update: Sept. 26, 2018