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Center for Nephrology and Metabolic Disorders
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Roundabout homolog 2

The ROBO2 gene encodes a transmembrane receptor. Mutations cause vesicoureteral reflux 2.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Familial vesicoureteral reflux 2
ROBO2

References:

1.

Lu W et al. (2007) Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

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2.

Kidd T et al. (1998) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.

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3.

Nagase T et al. (2000) Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

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4.

Fricke C et al. (2001) astray, a zebrafish roundabout homolog required for retinal axon guidance.

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5.

Bagri A et al. (2002) Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.

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6.

Grieshammer U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.

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7.

Yue Y et al. (2006) Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.

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8.

Xiao T et al. (2011) Assembly of lamina-specific neuronal connections by slit bound to type IV collagen.

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9.

NCBI article

NCBI 6092 external link
10.

OMIM.ORG article

Omim 602431 external link
11.

Orphanet article

Orphanet ID 289371 external link
12.

Wikipedia article

Wikipedia EN (ROBO2) external link
Update: Aug. 14, 2020
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