Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Oncogene WNT5A

The WNT5A gene encodes a secreted signal protein which is involved in oncogenesis and deveopment. Mutations cause autosomal dominant Robinow syndrome 1 characterized by multiple malformations.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Autosomal dominant Robinow syndrome 1
WNT5A

References:

1.

Kuss P et. al. (2014) Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A.

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2.

Gavin BJ et. al. (1990) Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

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3.

Robinow M et. al. (1969) A newly recognized dwarfing syndrome.

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4.

Clark CC et. al. (1993) Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.

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5.

He X et. al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A.

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6.

Yamaguchi TP et. al. (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.

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7.

Oishi I et. al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.

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8.

Mikels AJ et. al. (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.

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9.

Schleiffarth JR et. al. (2007) Wnt5a is required for cardiac outflow tract septation in mice.

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10.

Zhang X et. al. (2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C.

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11.

Witze ES et. al. (2008) Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.

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12.

Ford CE et. al. (2009) Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells.

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13.

Person AD et. al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome.

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14.

Stefater JA et. al. (2011) Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

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15.

Miyoshi H et. al. (2012) Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.

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16.

Florian MC et. al. (2013) A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.

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17.

Roifman M et. al. (2015) De novo WNT5A-associated autosomal dominant Robinow syndrome suggests specificity of genotype and phenotype.

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18.

Miyamoto DT et. al. (2015) RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

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Update: Sept. 26, 2018