Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Oncogene WNT5A

The WNT5A gene encodes a secreted signal protein which is involved in oncogenesis and deveopment. Mutations cause autosomal dominant Robinow syndrome 1 characterized by multiple malformations.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Autosomal dominant Robinow syndrome 1
WNT5A

References:

1.

Kuss P et al. (2014) Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A.

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2.

Robinow M et al. (1969) A newly recognized dwarfing syndrome.

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3.

Oishi I et al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.

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4.

Person AD et al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome.

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5.

Roifman M et al. (2015) De novo WNT5A-associated autosomal dominant Robinow syndrome suggests specificity of genotype and phenotype.

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6.

Gavin BJ et al. (1990) Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

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7.

Clark CC et al. (1993) Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.

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8.

He X et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A.

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9.

Yamaguchi TP et al. (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.

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10.

Mikels AJ et al. (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.

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11.

Schleiffarth JR et al. (2007) Wnt5a is required for cardiac outflow tract septation in mice.

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12.

Zhang X et al. (2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C.

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13.

Witze ES et al. (2008) Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.

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14.

Ford CE et al. (2009) Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells.

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15.

Stefater JA et al. (2011) Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

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16.

Miyoshi H et al. (2012) Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.

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17.

Florian MC et al. (2013) A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.

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18.

Miyamoto DT et al. (2015) RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

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19.

NCBI article

NCBI 7474 [^]
20.

OMIM.ORG article

Omim 164975 [^]
21.

Orphanet article

Orphanet ID 231387 [^]
22.

Wikipedia article

Wikipedia EN (WNT5A) [^]
Update: April 29, 2019