The NLRP2 encodes an nucleotide-binding protein which plays a role in immune response. Also iit seems to be involved in methylation, so an involvement in hypomethylation syndrome is hypothesized.
Clinic | Method | Carrier testing |
Turnaround | 5 days | |
Specimen type | genomic DNA |
Clinic | Method | Massive parallel sequencing |
Turnaround | 25 days | |
Specimen type | genomic DNA |
Research | Method | Genomic sequencing of the entire coding region |
Turnaround | 25 days | |
Specimen type | genomic DNA |
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1. |
Caliebe A et al. (2014) A familial disorder of altered DNA-methylation. ![]() |
2. |
Agostini L et al. (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. ![]() |
3. |
Tschopp J et al. (2003) NALPs: a novel protein family involved in inflammation. ![]() |
4. |
Bruey JM et al. (2004) PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. ![]() |
5. |
Peng H et al. (2012) Nlrp2, a maternal effect gene required for early embryonic development in the mouse. ![]() |
6. |
NCBI article NCBI 55655![]() |
7. |
OMIM.ORG article Omim 609364![]() |
8. |
Wikipedia article Wikipedia EN (NLRP2)![]() |