DNA (cytosine-5)-methyltransferase 1
The DNMT1 gene encodes a methyltransferase that is responsible for methylation of CpG islet in genomic DNA. So this emzyme plays an important role in gene silicing during development and epigenetic modification. Mutations cause autosomal dominant disorders such as autosomal dominant cerebellar ataxia, deafness and narcolepsy and hereditary sensory neuropathy type 1E.
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References:
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None (1997) Tying it all together: epigenetics, genetics, cell cycle, and cancer.
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Orphanet article
Orphanet ID 270026
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NCBI article
NCBI 1786
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OMIM.ORG article
Omim 126375
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Wikipedia article
Wikipedia EN (DNMT1)
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Update: Aug. 14, 2020